medRxiv : the preprint server for health sciences · 2021
The COVIDome Explorer Researcher Portal.
ПрепринтСтатьяНазвание и аннотация: Перевод в очереди
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Sullivan Kelly D, Galbraith Matthew D, Kinning Kohl T, Bartsch Kyle, Levinsky Nik, Araya Paula, Smith Keith P, Granrath Ross E, Shaw Jessica R, Baxter Ryan, Jordan Kimberly R, Russell Seth, Dzieciatkowska Monika, Reisz Julie A, Gamboni Fabia, Cendali Francesca, Ghosh Tusharkanti, Monte Andrew A, Bennett Tellen D, Miller Michael G, Hsieh Elena W Y, D'Alessandro Angelo, Hansen Kirk C, Espinosa Joaquin M
Аннотация
COVID-19 pathology involves dysregulation of diverse molecular, cellular, and physiological processes. In order to expedite integrated and collaborative COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19 patients including matched analysis of the whole blood transcriptome, plasma proteomics with two complementary platforms, cytokine profiling, plasma and red blood cell metabolomics, deep immune cell phenotyping by mass cytometry, and clinical data annotation. We refer to this multidimensional dataset as the COVIDome. We then created the COVIDome Explorer, an online researcher portal where the data can be analyzed and visualized in real time. We illustrate here the use of the COVIDome dataset through a multi-omics analysis of biosignatures associated with C-reactive protein (CRP), an established marker of poor prognosis in COVID-19, revealing associations between CRP levels and damage-associated molecular patterns, depletion of protective serpins, and mitochondrial metabolism dysregulation. We expect that the COVIDome Explorer will rapidly accelerate data sharing, hypothesis testing, and discoveries worldwide.