Combinatorial chemistry & high throughput screening · 2026
Hsa_circ_0030568 Promotes the Proliferation and Migration of Prostate Cancer Cells via the miR-141-3p-BRD4 Axis.
СтатьяНазвание и аннотация: Перевод в очереди
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Sun Chengwen, Xiang Congming, Wu Yuwei, Ge Dongsheng, Sun Xiaoxiao
Аннотация
INTRODUCTION: Numerous studies have indicated that circular RNAs (circRNAs) play an important role in diverse cancers. However, the specific molecular mechanism of circRNAs in prostate cancer (PCa) remains largely unclear.
METHOD: In this study, we performed western blotting, real-time quantitative polymerase chain reaction, CCK-8 assay, cell scratch wound assay, and RNA immunoprecipitation assay.
RESULTS: These results showed that the expression of hsa_circ_0030568 was remarkably increased in PCa cells by using quantitative real-time PCR combined with dataset analysis. Mechanistically, circ_0030568 could physically bind to miR-141-3p and elevate the expression of BRD4 via sponging miR-141-3p in PCa cells, then accelerating the progression of PCa. Upregulation of hsa_circ_0030568 induces tumor progression through the miR-141-3p-BRD4 axis.
CONCLUSION: Taken together, these findings suggested that hsa_circ_0030568 may act as a potential biomarker of PCa and a promising target for PCa treatment.
METHOD: In this study, we performed western blotting, real-time quantitative polymerase chain reaction, CCK-8 assay, cell scratch wound assay, and RNA immunoprecipitation assay.
RESULTS: These results showed that the expression of hsa_circ_0030568 was remarkably increased in PCa cells by using quantitative real-time PCR combined with dataset analysis. Mechanistically, circ_0030568 could physically bind to miR-141-3p and elevate the expression of BRD4 via sponging miR-141-3p in PCa cells, then accelerating the progression of PCa. Upregulation of hsa_circ_0030568 induces tumor progression through the miR-141-3p-BRD4 axis.
CONCLUSION: Taken together, these findings suggested that hsa_circ_0030568 may act as a potential biomarker of PCa and a promising target for PCa treatment.