Hsa_circ_0030568 Promotes the Proliferation and Migration of Prostate Cancer Cells via the miR-141-3p-BRD4 Axis.

INTRODUCTION

Numerous studies have indicated that circular RNAs (circRNAs) play an important role in diverse cancers. However, the specific molecular mechanism of circRNAs in prostate cancer (PCa) remains largely unclear.

METHOD: In this study, we performed western blotting, real-time quantitative polymerase chain reaction, CCK-8 assay, cell scratch wound assay, and RNA immunoprecipitation assay.

RESULTS

These results showed that the expression of hsa_circ_0030568 was remarkably increased in PCa cells by using quantitative real-time PCR combined with dataset analysis. Mechanistically, circ_0030568 could physically bind to miR-141-3p and elevate the expression of BRD4 via sponging miR-141-3p in PCa cells, then accelerating the progression of PCa. Upregulation of hsa_circ_0030568 induces tumor progression through the miR-141-3p-BRD4 axis.

CONCLUSION

Taken together, these findings suggested that hsa_circ_0030568 may act as a potential biomarker of PCa and a promising target for PCa treatment.