[Audiogenic seizure in the mouse according to strain and sex: the effect of the magnesium ration and neuromediators].

Mice of the DBA/2/M strain are audio-sensitive only for a short period (5 to 10 days). When this period is over, 100 p. 100 audiogenic seizures can be obtained with experimental magnesium deficiency. When AKR/R, OF1 and C57BL/R mice were deprived of magnesium for 15 or 21 days, they manifested an audiogenic attack only when given amphetamine sulfate, caffeine or isonicotinylhydrazine. If they had been deprived for 43 days, it was no longer necessary to administer these substances. The audiogenic attack could be prevented by correcting the deficiency with magnesium chloride or by preliminary administration of a single dose of various barbiturics, anti-convulsives, tranquillizers or parachlorophenylalanine, but not neuroleptics.