Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2014
[Telemetry EEG of parietal association cortex in heroin-induced CPP rats].
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Pan Qun-Wan, Zhu Zai-Man, Li Jing, Li Min, Zhou Hong-Min
Аннотация
OBJECTIVE: To determine the relationship between EEG changes of parietal association cortex (PtA) and drug-seeking behaviors of heroin-induced conditioned place preference (CPP) rats.
METHODS: Stereotaxic electrode was buried in the PtA of rats, which were then divided randomly into heroin-induced CPP group and operation-only control group. A CPP video system in combination with EEG wireless telemetry was used for recording PtA EEG and the behaviors of the rats-staying in black or white chamber of the video box; shuttling between black-white chambers or between white-black chambers.
RESULTS: No significant difference in percentage of the telemetry EEG waves was found between the two groups of rats when they stayed in the black or white chambers. The heroin-induced CPP rats had increased percentage of delta waves (P < 0.05) on the right PtA and decreased percentage of beta and beta2 waves on both right and left PtA (P < 0.05) when they shuttled between two chambers. Compared with the operation-only controls, significant decrease in the percentage of delta waves on both left and right PtA and increase in theta, alpha and alpha1 waves were evident (P < 0.05) only when the heroin-induced CPP rats shuttled between white-black chambers.
CONCLUSION: EEG changes on PtA of heroin-induced CPP rats differ between staying and shuttling states. Such changes may not be associated with drug-seeking behaviors.
METHODS: Stereotaxic electrode was buried in the PtA of rats, which were then divided randomly into heroin-induced CPP group and operation-only control group. A CPP video system in combination with EEG wireless telemetry was used for recording PtA EEG and the behaviors of the rats-staying in black or white chamber of the video box; shuttling between black-white chambers or between white-black chambers.
RESULTS: No significant difference in percentage of the telemetry EEG waves was found between the two groups of rats when they stayed in the black or white chambers. The heroin-induced CPP rats had increased percentage of delta waves (P < 0.05) on the right PtA and decreased percentage of beta and beta2 waves on both right and left PtA (P < 0.05) when they shuttled between two chambers. Compared with the operation-only controls, significant decrease in the percentage of delta waves on both left and right PtA and increase in theta, alpha and alpha1 waves were evident (P < 0.05) only when the heroin-induced CPP rats shuttled between white-black chambers.
CONCLUSION: EEG changes on PtA of heroin-induced CPP rats differ between staying and shuttling states. Such changes may not be associated with drug-seeking behaviors.