Cancer cell · 2026
CCL3 is produced by aged neutrophils across cancers and promotes tumor growth.
СтатьяНазвание и аннотация: Перевод в очереди
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Bolli Evangelia, Wirapati Pratyaksha, Hicham Mehdi, Xie Yuxuan, Siwicki Marie, Duval Florent, Goubet Anne-Gaëlle, Kiss Máté, Zitti Béatrice, Zwahlen Thomas, Mcdowell Sheri, Bill Ruben, Angerani Simona, Engblom Camilla, Anderson Seth, Jiang Aiping, Hartley Oliver, Sykes David B, Jankovic Maja, Fournier Nadine, Gunzer Matthias, Tarussio David, Tissot Stéphanie, Sadow Peter M, Faquin William C, Sade-Feldman Moshe, Weissleder Ralph, Pai Sara, Mercier François, Manguso Robert, Pittet Mikaël J
Аннотация
Tumor-associated neutrophils (TANs) are abundant across cancers, yet their phenotypic diversity and functional states remain poorly defined. Here, we introduce a cell-type probability classifier that recovers low-transcript neutrophils from scRNAseq datasets, enabling pan-cancer analyses of TAN heterogeneity. Across >190 human and murine tumors, we identify a conserved differentiation trajectory that culminates in a terminal CCL3hi state. This state exhibits pro-tumor transcriptional programs, including those involved in hypoxic adaptation and senescence. Consistently, CCL3hi TANs are enriched in hypoxic tumor niches in both humans and mice. Through mechanistic perturbations of neutrophil-derived CCL3 in mice, we show that it sustains TAN survival in hypoxic tumor regions via CCR1-dependent signaling. These findings establish CCL3 as a conserved marker and functional driver of pro-tumor neutrophils in growing tumors, and provide a scalable framework for dissecting neutrophil biology across cancer types.