Antibiotiki · 1976
[Interferonogenic and antiviral activity of the tobacco mosaic virus, tilorone and sodium nucleinate].
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Balezina T I, Fadeeva L L, Zemskov V M, Korneeva L E, Loĭdina G I
Аннотация
Production of endogenic interferon in animals in responce to administration of tobaco mozaic virus, tilorone and sodium nucleinate was shown. Dependence of interferon production on the type of the inductor and the route of its administration was studied. Absolute innocuiuty of the tobaco mozaic virus for monkeys (macaco-resus) and mice, as well as the absence of any side effects in humans treated with it perorally was shown. The tobaco mozaic virus, tilorone and sodium nucleinate used perorally in treatment of experimental infections of mice caused by the viruses of East and West encephalomyelitis, influenza and tick encephalitis had a pronounced protective effect.
Предметные рубрики MeSH
AnimalsAntiviral AgentsBirdsCells, CulturedCytotoxicity Tests, ImmunologicDose-Response Relationship, DrugDrug Evaluation, PreclinicalEncephalitisEncephalitis Virus, Eastern EquineEncephalitis Virus, Western EquineEncephalitis, Tick-BorneFluorenesHaplorhiniHumansInfluenza, HumanInterferon InducersInterferonsMacacaMiceNewcastle DiseaseNucleic AcidsTiloroneTime FactorsTobacco Mosaic Virus