Cytogenetic analysis of 10,286 cases with male infertility.

PURPOSE: Chromosome analysis of 10,286 cases with male infertility and to discuss the genetic causes of male infertility.

MATERIALS AND

METHODS

10,286 patients with azoospermia and oligoasthenozoospermia were collected in the present center from January 2009 to January 2013.Peripheral blood lymphocyte culture and chromosome analysis were performed.

RESULTS

In all the 10,286 cases with azoospermia and oligoasthenozoospermia, 8,401 cases showed normal karyotype, 538 cases had chromosome polymorphism, accounting for 5.2% and 1,378 cases had chromosomal abnormalities with a frequency of 13.4%;

Conclusions

Genetic factors are closely related to the occurrence of azoospermia and oligoasthenozoospermia, and chromosome analysis in patients with male infertility is necessary.