[Metabolic features of the liver and spleen and antibody formation in animals following hyperimmunization with viral antigens].

Hyperimmunization with the tick encephalitis and Western horse encephalomyelitis viruses reproduced in the brain of albino mice, intensified the protein synthesis in the splenic tissue during the productive phase of the immunogenesis (the 7th day). An accumalation of protein, activation of aniuno-acyl-t-RNA-ligases, a reduction of the concehtration of some amino acids was noted, An analogous reaction was distinct in the tissue of the liver only when an intact brain suspension was used as an antigen. Formation of specific antibodies coursed more intensively after the administration of a more pathogenic virusof Western equine encephalomyelitis.