American journal of reproductive immunology (New York, N.Y. : 1989) · 2016
Effect of chronic glomerulonephritis on the semen quality and cytokines in the semen of infertile males.
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Zhang Huina, Ying Yingfen, Chen Yilu, Lu Xiaosheng, Huang Yonggang
Аннотация
PROBLEM: The effects of chronic glomerulonephritis (CGN) on semen quality and cytokine levels in the semen of infertile males remain undetermined.
METHOD OF STUDY: Fifty-eight semen samples from normal males and CGN males with and without infertility, respectively, were analyzed.
RESULTS: Semen volume, semen pH, sperm density, percentage of forward movement of sperm, sperm activate rate, sperm survival rate, and rate of normal sperm morphology of infertility males with CGN were significantly lower than those of CGN males without infertility and normal males (P<.05). In addition, the blood urea nitrogen and serum creatinine levels and interleukin (IL)-17 and IL-18 levels in infertility males with CGN were significantly higher than those of CGN males without infertility and normal males (P<.05).
CONCLUSIONS: CGN increased the blood urea nitrogen and serum creatinine levels, which induced abnormal expression of IL-17 and IL-18, and negatively affected male semen quality and might result in male infertility.
METHOD OF STUDY: Fifty-eight semen samples from normal males and CGN males with and without infertility, respectively, were analyzed.
RESULTS: Semen volume, semen pH, sperm density, percentage of forward movement of sperm, sperm activate rate, sperm survival rate, and rate of normal sperm morphology of infertility males with CGN were significantly lower than those of CGN males without infertility and normal males (P<.05). In addition, the blood urea nitrogen and serum creatinine levels and interleukin (IL)-17 and IL-18 levels in infertility males with CGN were significantly higher than those of CGN males without infertility and normal males (P<.05).
CONCLUSIONS: CGN increased the blood urea nitrogen and serum creatinine levels, which induced abnormal expression of IL-17 and IL-18, and negatively affected male semen quality and might result in male infertility.