Fertility and sterility · 1999
Spontaneous abortion: a randomized, controlled trial comparing surgical evacuation with conservative management using misoprostol.
Клиническое исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Chung T K, Lee D T, Cheung L P, Haines C J, Chang A M
Аннотация
OBJECTIVE: To compare the efficacy of surgical evacuation of the uterus with medical evacuation using misoprostol in cases of spontaneous abortion.
DESIGN: A prospective, randomized, controlled trial.
SETTING: A university teaching hospital.
PATIENT(S): Six hundred thirty-five women who aborted spontaneously and who consented to pretreatment randomization.
INTERVENTION(S): Routine surgical evacuation or medical evacuation of the uterus using misoprostol.
MAIN OUTCOME MEASURE(S): Immediate, short-term (2-3 weeks), and medium-term (6 months) medical complications.
RESULT(S): There was a significantly lower incidence of immediate and short-term complications in the group treated with misoprostol compared with the surgically treated group. There were also fewer major complications in the 6 months after treatment in the medically treated group. Approximately 50% of the medically treated group subsequently required surgical evacuation, and these subjects required significantly more analgesia.
CONCLUSION(S): Treatment with misoprostol can reduce the demand for surgical evacuation in cases of spontaneous abortion, and its use is associated with fewer medical complications.
DESIGN: A prospective, randomized, controlled trial.
SETTING: A university teaching hospital.
PATIENT(S): Six hundred thirty-five women who aborted spontaneously and who consented to pretreatment randomization.
INTERVENTION(S): Routine surgical evacuation or medical evacuation of the uterus using misoprostol.
MAIN OUTCOME MEASURE(S): Immediate, short-term (2-3 weeks), and medium-term (6 months) medical complications.
RESULT(S): There was a significantly lower incidence of immediate and short-term complications in the group treated with misoprostol compared with the surgically treated group. There were also fewer major complications in the 6 months after treatment in the medically treated group. Approximately 50% of the medically treated group subsequently required surgical evacuation, and these subjects required significantly more analgesia.
CONCLUSION(S): Treatment with misoprostol can reduce the demand for surgical evacuation in cases of spontaneous abortion, and its use is associated with fewer medical complications.