Медицинская библиотека · Future oncology (London, England) · 2021

Eribulin in brain metastases of breast cancer: outcomes of the EBRAIM prospective observational trial.

Fabi Alessandra, Terrenato Irene, Vidiri Antonello, Villani Veronica, Tanzilli Antonio, Airoldi Mario, Pedani Fulvia, Magri Valentina, Palleschi Michela, Donadio Michela, Catania Giovanni, Nisticò Cecilia, Carapella Carmine, Rudà Roberta, Pace Andrea, Maschio Marta, Telera Stefano, Cognetti Francesco, AINO (Associazione Italiana Neuro-Oncologia)

СтатьяМногоцентровое исследованиеНаблюдательное исследованиеПеревод в очереди

Аннотация

Background

Eribulin shows some activity in controlling brain metastasis in breast cancer.

Methods

This observational, multicenter study evaluated brain disease control rates, survival and safety in patients with brain metastatic breast cancer treated with eribulin in clinical practice.

Results

A total of 34 patients were enrolled (mean age 49 years, 91% with visceral metastases) and 29 were evaluable for brain disease. Fourteen achieved disease control and showed a longer time without progression: 10 months (95% CI: 2.3-17.7) versus 4 months (95% CI: 3.3-4.7) in the control group (p = 0.029). Patients with clinical benefits at 6 months had longer survival. Leukopenia and neutropenia were the most frequent grade 3-4 toxicities.

Conclusion

Eribulin confirms its effectiveness in patients with brain metastatic breast cancer. Further studies on larger cohorts are needed to confirm the results.

Для цитирования: Fabi Alessandra, Terrenato Irene, Vidiri Antonello, Villani Veronica, Tanzilli Antonio, Airoldi Mario, Pedani Fulvia, Magri Valentina, Palleschi Michela, Donadio Michela, Catania Giovanni, Nisticò Cecilia, Carapella Carmine, Rudà Roberta, Pace Andrea, Maschio Marta, Telera Stefano, Cognetti Francesco, AINO (Associazione Italiana Neuro-Oncologia). Eribulin in brain metastases of breast cancer: outcomes of the EBRAIM prospective observational trial.. Future oncology (London, England). 2021. DOI: 10.2217/fon-2021-0300.

Предметные рубрики MeSH

Adult Aged Brain Neoplasms Breast Neoplasms Female Follow-Up Studies Furans Humans Ketones Middle Aged Prognosis Prospective Studies Survival Rate Polyether Polyketides

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