Delayed complication of botulinum toxin and hyaluronic acid filler injections: A case report.

BACKGROUND

Botulinum toxin and hyaluronic acid (HA) filler injections are popular minimally invasive cosmetic procedures owing to their convenience, efficiency, and durability; however, adverse reactions often occur.

MATERIALS AND

METHODS

We describe the delayed hypersensitivity reaction that occurred after sequential injections of botulinum toxin and HA filler.

RESULTS

The histopathologic and dermatoscopic findings suggested a delayed hypersensitivity reaction with the formation of a dermal foreign body granuloma. The rash resolved 2 months following treatment with antihistamines and topical steroids cream.

CONCLUSION

We assume that local trauma during the blepharoplasty stimulated an immune response, which was the basis for this complication.