Journal of medical virology · 2023
Two novel recombinant human mastadenovirus D genotypes associated with acute respiratory illness.
СтатьяПоддержка службы здравоохранения СШАПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Gonzalez Gabriel, Hayes Matthew, Balansay Melinda, Underwood Ryan, Balagot Caroline, Pan Roger, Pineda Kyle, Iniguez-Stevens Esmeralda, Kriner Paula, Estrada Irais, Myers Christopher A, Kajon Adriana E
Аннотация
Two novel genotypes of species human mastadenovirus D designated 109 and 110 were isolated from three epidemiologically unrelated cases of acute respiratory disease detected in January 2018 by surveillance efforts at the California/Mexico border. Both genotypes represent examples of intertypic recombination. Genotype D109 is most closely related to genotype D56 (97.68% genomic similarity) and features a type D22-like penton base, a type D19-like hexon gene, and a type D9-like fiber [P22/H19/F9]. On the other hand, genotype D110 is most closely related to type D22 (96.94% genomic similarity) and features a type D67-like penton base, a novel hexon gene, and a type D9-like fiber [P67/H110/F9]. Importantly, the fibers of both novel genotypes are highly similar to those of genotypes D56 and D59, which have also been isolated from a few cases of respiratory infections. The present report shows data contributing to the understanding of the molecular determinants of the expanded tissue tropism of certain members of species HAdV-D.