Fundamental and clinical neuropharmacology, a terra incognita with constantly expanding frontiers.

Neuropharmacology is the science that studies the effects of drugs on the central nervous system. Examining the recent history of neuropharmacology allows us to identify future challenges and to project into the future. The contemporary history of neuropharmacology begins with the empirical use of psychotropic alkaloids in barbiturate preparations. Then the discovery of neuroleptics in the 1950s truly opened up the field of pharmacological science, with psychopharmacological clinical exploration in psychiatry, complemented by the contributions of neurochemists and biochemists discovering and exploring neurotransmission. These studies also contributed to the development of dopaminergic and serotonergic drugs used in neurology. The more recent period brought the advent of neuropsychopharmacology, sharing therapeutic targets in neurology and psychiatry on the one hand, and a translational research approach on the other. Moreover, the pharmacology of brain drugs is still a growing discipline in 2020. Despite emerging pharmacological concepts (biased agonists, glial targeting, epigenetic therapeutics, etc.), entire areas of brain-based therapeutics need to be renewed, particularly in psychiatry, offering great challenges to a new generation of pharmacologists and clinicians.