Fertility and sterility · 2019
Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis.
Сравнительное исследованиеСтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Heijligers Malou, Peeters Andrea, van Montfoort Aafke, Nijsten Joyce, Janssen Etienne, Gunnewiek Femke Klein, de Rooy Rick, van Golde Ron, Coonen Edith, Meijer-Hoogeveen Madelon, Broekmans Frank, van der Hoeven Mark, Arens Yvonne, de Die-Smulders Christine
Аннотация
OBJECTIVE: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD).
DESIGN: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC).
SETTING: University hospital.
PATIENT(S): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC.
INTERVENTION(S): PGD.
MAIN OUTCOME MEASURE(S): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones.
RESULT(S): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems.
CONCLUSION(S): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder.
TRIAL REGISTRATION NUMBER: NCT02149485.
DESIGN: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC).
SETTING: University hospital.
PATIENT(S): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC.
INTERVENTION(S): PGD.
MAIN OUTCOME MEASURE(S): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones.
RESULT(S): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems.
CONCLUSION(S): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder.
TRIAL REGISTRATION NUMBER: NCT02149485.
Предметные рубрики MeSH
Age FactorsBlood PressureBody HeightBody Mass IndexChild DevelopmentChild HealthChild, PreschoolFemaleFertilization in VitroGenetic Diseases, InbornGenetic TestingHealth StatusHumansInfertilityMaleMotor SkillsPreimplantation DiagnosisRisk AssessmentRisk FactorsSperm Injections, IntracytoplasmicTreatment OutcomeWeight Gain