Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2010
Effects of two different low-dose oral contraceptives on plasma homocysteine levels.
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Odabaşi Ali R, Küçük Mert, Yüksel Hasan, Güner Zekeriya, Sezer Selda D
Аннотация
OBJECTIVE: The aim of this study was to investigate the effects of two currently used low-dose combined oral contraceptives (COCs) (20 μg ethinyl estradiol [EE]/150 μg desogestrel [DSG] vs. 20 μg EE/100 μg levonorgestrel [LNG]) on plasma homocysteine levels.
METHODS: A total of 90 participants were enrolled in the study; 30 of them had not been using COC for at least 12 months prior to their enrollment, while 60 were on regular treatment within 12-18 months. Therefore, the control group consisted of 30 participants. Group DSG/EE consisted of 30 women and group LNG/EE consisted of 30 women. Serum samples of homocysteine profile were obtained during the early follicular phase.
RESULTS: Significantly lower serum homocysteine concentrations (Group DSG/EE: 7.2 +/- 1.3; Group LNG/EE: 9.1 +/- 3.2;
CONTROL GROUP: 8.2 +/- 2.2; p<0.05) were observed in DSG/EE group compared to LNG/EE and control groups.
CONCLUSION: Although the decrease in homocysteine levels with 20 μg EE/150 μg DSG containing COC was statistically significant, the clinical relevance of our findings needs to be further investigated.
METHODS: A total of 90 participants were enrolled in the study; 30 of them had not been using COC for at least 12 months prior to their enrollment, while 60 were on regular treatment within 12-18 months. Therefore, the control group consisted of 30 participants. Group DSG/EE consisted of 30 women and group LNG/EE consisted of 30 women. Serum samples of homocysteine profile were obtained during the early follicular phase.
RESULTS: Significantly lower serum homocysteine concentrations (Group DSG/EE: 7.2 +/- 1.3; Group LNG/EE: 9.1 +/- 3.2;
CONTROL GROUP: 8.2 +/- 2.2; p<0.05) were observed in DSG/EE group compared to LNG/EE and control groups.
CONCLUSION: Although the decrease in homocysteine levels with 20 μg EE/150 μg DSG containing COC was statistically significant, the clinical relevance of our findings needs to be further investigated.