Hepato-gastroenterology · 2010
Effect of hepatic blood inflow occlusion without hemihepatic artery control on apoptosis of liver cells in rats.
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Jin Shan, Dai Chaoliu, Yang Yuntian, Zhang Ruiming, Sileng A
Аннотация
BACKGROUND/AIMS: To investigate the effect of hepatic blood inflow occlusion without hemihepatic artery control on the apoptosis of liver cells during ischemia-reperfusion injury in rats.
METHODOLOGY: Animal models of three hepatic vascular occlusion methods were established. Hepatic blood inflow occlusion without hemihepatic artery control (WH group), hemihepatic vascular occlusion (HH group) and Pringle maneuver (PR group) were compared.
RESULTS: At each time point after reperfusion, ALT, AST, and apoptosis rates were significantly higher in the PR group than in the HH group or the WH group (p < 0.01), and the pathology and hepatocyte ultrastructure at 6 hours after reperfusion were significantly worse in the PR group than in the HH group or the WH group (p < 0.01). ALT, AST, apoptosis rate, pathology and hepatocyte ultrastructure at 6 hours after reperfusion were not significantly different between the WH group and the HH group (p > 0.05).
CONCLUSION: Hepatic blood inflow occlusion without hemihepatic artery control can reduce hepatic ischemia-reperfusion injury, and the effect is similar to that of hemihepatic vascular occlusion.
METHODOLOGY: Animal models of three hepatic vascular occlusion methods were established. Hepatic blood inflow occlusion without hemihepatic artery control (WH group), hemihepatic vascular occlusion (HH group) and Pringle maneuver (PR group) were compared.
RESULTS: At each time point after reperfusion, ALT, AST, and apoptosis rates were significantly higher in the PR group than in the HH group or the WH group (p < 0.01), and the pathology and hepatocyte ultrastructure at 6 hours after reperfusion were significantly worse in the PR group than in the HH group or the WH group (p < 0.01). ALT, AST, apoptosis rate, pathology and hepatocyte ultrastructure at 6 hours after reperfusion were not significantly different between the WH group and the HH group (p > 0.05).
CONCLUSION: Hepatic blood inflow occlusion without hemihepatic artery control can reduce hepatic ischemia-reperfusion injury, and the effect is similar to that of hemihepatic vascular occlusion.