Fertility and sterility · 2010
Endothelial function in patients with polycystic ovary syndrome: a long-term follow-up study.
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Hudecova Miriam, Holte Jan, Olovsson Matts, Lind Lars, Poromaa Inger Sundström
Аннотация
OBJECTIVE: To investigate pulse wave reflection and endothelial-dependent vasodilation in patients with polycystic ovary syndrome (PCOS) and age-matched healthy controls.
DESIGN: Long-term follow-up study.
SETTING: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
PATIENT(S): Sixty-seven patients with PCOS and with a mean age of 43.3 years at the follow-up investigation and 66 age-matched controls.
INTERVENTION(S): Aplanation tonometry before and after β-2 receptor agonist (terbutaline) challenge.
MAIN OUTCOME MEASURE(S): Baseline augmentation index (AI) aorta, baseline AI-radial, and change in AI-radial after terbutaline administration as a measure of endothelial-dependent vasodilation.
RESULT(S): There was no difference in baseline AI-aorta between patients with PCOS and control subjects. Change in AI-radial after terbutaline administration was less pronounced in patients with PCOS compared with control subjects. This difference remained when adjusted for use of combined oral contraceptives (OC)/hormone replacement therapy (HT) and postmenopausal status but not after adjustment for body mass index (BMI).
CONCLUSION(S): Middle-aged patients with PCOS display signs of endothelial dysfunction in comparison to age-matched controls, but this is largely due to the increased prevalence of independent risk factors for cardiovascular disease found in this group.
DESIGN: Long-term follow-up study.
SETTING: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
PATIENT(S): Sixty-seven patients with PCOS and with a mean age of 43.3 years at the follow-up investigation and 66 age-matched controls.
INTERVENTION(S): Aplanation tonometry before and after β-2 receptor agonist (terbutaline) challenge.
MAIN OUTCOME MEASURE(S): Baseline augmentation index (AI) aorta, baseline AI-radial, and change in AI-radial after terbutaline administration as a measure of endothelial-dependent vasodilation.
RESULT(S): There was no difference in baseline AI-aorta between patients with PCOS and control subjects. Change in AI-radial after terbutaline administration was less pronounced in patients with PCOS compared with control subjects. This difference remained when adjusted for use of combined oral contraceptives (OC)/hormone replacement therapy (HT) and postmenopausal status but not after adjustment for body mass index (BMI).
CONCLUSION(S): Middle-aged patients with PCOS display signs of endothelial dysfunction in comparison to age-matched controls, but this is largely due to the increased prevalence of independent risk factors for cardiovascular disease found in this group.