What's the Mtrr with your grandparents?

Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descendants for up to four generations.