The interrelationship between phosphate and magnesium metabolism.

a) It appears that the interrelationship between phosphate and magnesium metabolism is complicated and the mechanisms involved are not fully understood, b) the interaction between the homeostasis of these two ions is species dependent and its full expression is most evident in the rat, c) body depletion of either of these ions may result in marked changes in the blood levels, intestinal absorption, renal handling and body content of the other, d) hypermagnesemia causes hyperphosphatemia and decreased urinary excretion of phosphate, and e) the effects of hyperphosphatemia on magnesium are not elucidated as yet.