BMC research notes · 2013
Membranous nephropathy with acquired factor V inhibitor: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kitamura Shinji, Misawa Mahito, Namba Sayaka, Tsuji Kenji, Torigoe Rikako, Shima Midori, Makino Hirofumi
Аннотация
BACKGROUND: Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. In contrast, acquired factor V inhibitor is a rare bleeding disorder.
CASE PRESENTATION: A 62-year-old Asian man with a history of cerebral hemorrhage, purpura, eosinophilia and hyper immunoglobulin E syndrome developed proteinuria. The bleeding disorder was diagnosed with acquired factor V inhibitors. A renal biopsy revealed that he suffered from membranous nephropathy with glomerular endothelial damage which is reported to be involved in another factor disorder. After the steroid administration, the coagulation test and proteinuria were improved.
CONCLUSIONS: The presence of factor V inhibitors may have been involved in the development of membranous nephropathy.
CASE PRESENTATION: A 62-year-old Asian man with a history of cerebral hemorrhage, purpura, eosinophilia and hyper immunoglobulin E syndrome developed proteinuria. The bleeding disorder was diagnosed with acquired factor V inhibitors. A renal biopsy revealed that he suffered from membranous nephropathy with glomerular endothelial damage which is reported to be involved in another factor disorder. After the steroid administration, the coagulation test and proteinuria were improved.
CONCLUSIONS: The presence of factor V inhibitors may have been involved in the development of membranous nephropathy.