Medicine · 2020
Withdrawing mycophenolate mofetil in treating a young kidney transplant recipient with COVID-19: A case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Chen Dong, Yang Bo, Zhang Yan, Chen Liang, Wei Lai, Zhang Weijie, Wang Xinqiang, Tong Xiaolin, Chen Zhishui
Аннотация
RATIONALE: Coronavirus disease 2019 (COVID-19) is a novel infectious disease and became a global issue. Treatment of COVID-19 especially in solid organ transplant recipients is empirical and controversial, especially the adjustment of the immunosuppressants.
PATIENT CONCERNS: A 29-year-old kidney transplant recipient with the symptoms of COVID-19 pneumonia.
DIAGNOSES: COVID-19 pneumonia after kidney transplantation.
INTERVENTIONS: He was treated with modified immunosuppressants (unchanged dose of tacrolimus and oral corticosteroids while discontinuing mycophenolate mofetil (MMF)), antibiotics, interferon α-2b inhalation and traditional Chinese medicine.
OUTCOMES: He recovered from COVID-19 pneumonia after 29 days of hospitalization. And the renal function (measured as blood urea nitrogen, serum creatinine, and urine protein) returned to normal.
LESSONS: In certain group of COVID-19 (e.g., mild to moderate cases, young patients without comorbidities), a reduction instead of an overall withdrawal of immunosuppressant in kidney transplant recipients is feasible.
PATIENT CONCERNS: A 29-year-old kidney transplant recipient with the symptoms of COVID-19 pneumonia.
DIAGNOSES: COVID-19 pneumonia after kidney transplantation.
INTERVENTIONS: He was treated with modified immunosuppressants (unchanged dose of tacrolimus and oral corticosteroids while discontinuing mycophenolate mofetil (MMF)), antibiotics, interferon α-2b inhalation and traditional Chinese medicine.
OUTCOMES: He recovered from COVID-19 pneumonia after 29 days of hospitalization. And the renal function (measured as blood urea nitrogen, serum creatinine, and urine protein) returned to normal.
LESSONS: In certain group of COVID-19 (e.g., mild to moderate cases, young patients without comorbidities), a reduction instead of an overall withdrawal of immunosuppressant in kidney transplant recipients is feasible.
Предметные рубрики MeSH
AdultAnti-Bacterial AgentsAnti-Inflammatory AgentsAntiviral AgentsBetacoronavirusCOVID-19Coronavirus InfectionsDrugs, Chinese HerbalHumansImmunosuppressive AgentsInterferon alpha-2Kidney TransplantationMaleMycophenolic AcidOxygen Inhalation TherapyPandemicsPneumonia, ViralSARS-CoV-2Treatment OutcomeCOVID-19 Drug Treatment