Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 2002
[Experimental study on liver protective effect of Artemisia rupestris extract].
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Israpil, Abdiryim, Gulnar
Аннотация
OBJECTIVE: To explore the protective effect of Artemisia rupestris extract (ARE) on chemical liver injury and immunological hepatitis.
METHODS: Mice model of immunological hepatitis was established by lipopolysaccharide plus Bacillus Calmette-Guérin vaccine (BCG), and the models of liver injury was induced by D-galactosamine or carbon tetrachloride (CCl4) in mice and rats. The effects of ARE in preventing and treating immunological hepatitis and protecting liver injury were observed.
RESULTS: ARE significantly lowered the serum alanine transaminase (ALT) in immunological hepatitis (P < 0.05), CCl4 induced liver injury model mice and rats (P < 0.01), and in D-galactosamine induced liver injury mice (P < 0.05).
CONCLUSION: ARE has significantly protective effect against chemical liver injury and could treat immunological hepatitis, but with no effect in preventing immunological hepatitis. These might be the partial pharmacologic basis for using ARE in treating hepatitis.
METHODS: Mice model of immunological hepatitis was established by lipopolysaccharide plus Bacillus Calmette-Guérin vaccine (BCG), and the models of liver injury was induced by D-galactosamine or carbon tetrachloride (CCl4) in mice and rats. The effects of ARE in preventing and treating immunological hepatitis and protecting liver injury were observed.
RESULTS: ARE significantly lowered the serum alanine transaminase (ALT) in immunological hepatitis (P < 0.05), CCl4 induced liver injury model mice and rats (P < 0.01), and in D-galactosamine induced liver injury mice (P < 0.05).
CONCLUSION: ARE has significantly protective effect against chemical liver injury and could treat immunological hepatitis, but with no effect in preventing immunological hepatitis. These might be the partial pharmacologic basis for using ARE in treating hepatitis.