Journal of addiction medicine · 2013
Associations among hypothalamus-pituitary-adrenal axis function, novelty seeking, and retention in methadone maintenance therapy for heroin dependency.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lin Shih-Hsien, Chen Wei Tseng, Chen Kao Chin, Lee Sheng-Yu, Lee I Hui, Chen Po See, Yeh Tzung Lieh, Lu Ru-Band, Yang Yen Kuang
Аннотация
OBJECTIVE: The efficacy of methadone maintenance therapy for heroin dependence is compromised by the low retention rate. Hypothalamus-pituitary-adrenal (HPA) axis function, which is associated with stress response, and novelty seeking (NS), a personality trait associated with low dopaminergic activity, may play roles in retention.
METHOD: We conducted a prospective study in which HPA axis function and NS were assessed by the dexamethasone suppression test and the Tridimensional Personality Questionnaire at baseline, respectively. The retention rate was assessed at the half- and 1-year points of methadone maintenance therapy.
RESULTS: A low suppression rate of dexamethasone suppression test (D%) was associated with a high level of NS. A low D% was associated with half-year dropout, whereas a high level of NS was associated with 1-year dropout. Survival analysis confirmed that D% and NS were significant time-dependent covariates for retention.
CONCLUSION: The findings showed that HPA axis function and NA were associated with retention at different time points.
METHOD: We conducted a prospective study in which HPA axis function and NS were assessed by the dexamethasone suppression test and the Tridimensional Personality Questionnaire at baseline, respectively. The retention rate was assessed at the half- and 1-year points of methadone maintenance therapy.
RESULTS: A low suppression rate of dexamethasone suppression test (D%) was associated with a high level of NS. A low D% was associated with half-year dropout, whereas a high level of NS was associated with 1-year dropout. Survival analysis confirmed that D% and NS were significant time-dependent covariates for retention.
CONCLUSION: The findings showed that HPA axis function and NA were associated with retention at different time points.
Предметные рубрики MeSH
Adaptation, PsychologicalAdultDexamethasoneExploratory BehaviorFemaleGlucocorticoidsHeroin DependenceHumansHypothalamo-Hypophyseal SystemMaleMedication Therapy ManagementMethadoneMiddle AgedNarcoticsOpiate Substitution TreatmentPatient DropoutsPersonalityPersonality AssessmentPituitary-Adrenal SystemProspective StudiesSurvival AnalysisUnited States