Медицинская библиотека · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 2000

[Observation on dynamic changes of serum procollagen III, hyaluronic acid and laminin in rats with hepatic fibrosis treated with Hujin pill].

Huang Z, Li Q, Wang Z

Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To study the dynamic changes of serum procollagen III (PCIII), hyaluronic acid (HA) and laminin (LN) in rats with hepatic fibrosis treated with Hujin pill (HJP).

METHODS

The classic model of hepatic fibrosis induced by CCl4 were used in the observation. The serum PCIII, HA and LN were determined by radioimmunoassay (RIA).

RESULTS

HJP could reduce the serum HA, LN content significantly, as compared with the control group, the difference was significant (P < 0.05, P < 0.01). Its long-term therapeutic effect was better than that of colchicine. It could maintain the serum PCIII stable in hepato-fibrotic stage (9-12 weeks), as compared with the normal control group, the difference was insignificant (P > 0.05).

CONCLUSION

HJP could retard the liver fibrosis, and has good preventive and therapeutic effect on liver fibrosis in rats.

Для цитирования: Huang Z, Li Q, Wang Z. [Observation on dynamic changes of serum procollagen III, hyaluronic acid and laminin in rats with hepatic fibrosis treated with Hujin pill].. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2000.

Предметные рубрики MeSH

Animals Carbon Tetrachloride Poisoning Drugs, Chinese Herbal Hyaluronic Acid Laminin Liver Cirrhosis, Experimental Male Phytotherapy Procollagen Rats Rats, Sprague-Dawley

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