Медицинская библиотека · Annals of clinical and laboratory science · 2022

Silence of FIZZ1 by Short Hairpin RNA Inhibits Atherosclerosis.

Tang Feng, Yang Fan, Li Tong, Yang Yongyao, Deng Jiusheng

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Аннотация

OBJECTIVE

Found in Inflammatory Zone 1 (FIZZ1) protein plays an important enhancive role in inflammation and angiogenesis. This study aims to explore the effects of FIZZ1 on murine atherosclerosis.

METHODS

The murine aortic endothelial cells were treated with an adenoviral vector encoding FIZZ1 short hairpin RNA (Ad-shFIZZ1). Murine atherosclerosis model was established with ApoE-/- mice. The effects of FIZZ1 were studied in vitro and in vivo.

RESULTS

Ad-shFIZZ1 treatment suppressed the expression of FIZZ1 and the formation of capillary tube formation in vitro. Administration of Ad-shFIZZ1 suppressed FIZZ1-mediated signaling, the growth of endothelial cells and the production of inflammatory molecules in murine aorta in vivo, and inhibited the development of atherosclerosis in vivo.

CONCLUSION

FIZZ1 played a potent promotive role in atherosclerosis, and could serve as a novel therapeutic target for the treatment of the disease.

Для цитирования: Tang Feng, Yang Fan, Li Tong, Yang Yongyao, Deng Jiusheng. Silence of FIZZ1 by Short Hairpin RNA Inhibits Atherosclerosis.. Annals of clinical and laboratory science. 2022.

Предметные рубрики MeSH

Animals Atherosclerosis Endothelial Cells Humans Inflammation Intercellular Signaling Peptides and Proteins Mice Mice, Inbred C57BL RNA, Small Interfering

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