Archives of disease in childhood. Fetal and neonatal edition · 2001
Non-invasive assessment of shunt and ventilation/perfusion ratio in neonates with pulmonary failure.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Smith H L, Jones J G
Аннотация
AIMS: To make non-invasive measurements of right to left (R-L) shunt and reduced ventilation/perfusion ratio (V(A)/Q) in neonates with pulmonary failure and to examine sequential changes in these variables after treatment.
METHODS: Twelve neonates with pulmonary failure were studied. They ranged in gestational age from 24 to 37 (median 27) weeks and were 1-39 (median 4) days old. Shunt and reduced V(A)/Q were derived from their effects on the relation between inspired oxygen pressure (PIO(2)) and arterial oxygen saturation measured with a pulse oximeter (SpO(2)). Pairs of PIO(2) v. SpO(2) data points were obtained by varying PIO(2) in a stepwise fashion. A computer algorithm based on a model of pulmonary gas exchange fitted a curve to these data. With PIO(2) on the abscissa, an increase in shunt produced a downward movement of the curve, whereas reducing V(A)/Q to < 0.8 shifted the curve to the right. The right shift gives a variable that is inversely related to V(A)/Q, the PIO(2) - PO(2) difference, where PO(2) is mixed capillary oxygen pressure.
RESULTS: Ten of the 12 infants on the first study day had large shunts (range 5.9-31.0%, median 19.9%, normal < 8%) and large PIO(2) - PO(2) differences (range 9.7-64.4 kPa, median 19.8 kPa, normal < 7 kPa) equivalent to a median V(A)/Q of 0.2 (normal median V(A)/Q = 0.8). Sequential improvement in shunt and V(A)/Q were shown in most infants after treatment. Sudden large changes in these variables were shown in two infants.
CONCLUSION: This simple non-invasive method distinguishes between shunt and reduced V(A)/Q in neonates with pulmonary failure.
METHODS: Twelve neonates with pulmonary failure were studied. They ranged in gestational age from 24 to 37 (median 27) weeks and were 1-39 (median 4) days old. Shunt and reduced V(A)/Q were derived from their effects on the relation between inspired oxygen pressure (PIO(2)) and arterial oxygen saturation measured with a pulse oximeter (SpO(2)). Pairs of PIO(2) v. SpO(2) data points were obtained by varying PIO(2) in a stepwise fashion. A computer algorithm based on a model of pulmonary gas exchange fitted a curve to these data. With PIO(2) on the abscissa, an increase in shunt produced a downward movement of the curve, whereas reducing V(A)/Q to < 0.8 shifted the curve to the right. The right shift gives a variable that is inversely related to V(A)/Q, the PIO(2) - PO(2) difference, where PO(2) is mixed capillary oxygen pressure.
RESULTS: Ten of the 12 infants on the first study day had large shunts (range 5.9-31.0%, median 19.9%, normal < 8%) and large PIO(2) - PO(2) differences (range 9.7-64.4 kPa, median 19.8 kPa, normal < 7 kPa) equivalent to a median V(A)/Q of 0.2 (normal median V(A)/Q = 0.8). Sequential improvement in shunt and V(A)/Q were shown in most infants after treatment. Sudden large changes in these variables were shown in two infants.
CONCLUSION: This simple non-invasive method distinguishes between shunt and reduced V(A)/Q in neonates with pulmonary failure.