Journal of dentistry for children (Chicago, Ill.) · 2013
Efficacy and safety of midazolam for sedation in pediatric dentistry: a controlled clinical trial.
Контролируемое клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Azevedo Isabelita Duarte, Ferreira Maria Angela Fernandes, da Costa Anna Paula Serejo, Bosco Vera Lúcia, Moritz Rachel Duarte
Аннотация
PURPOSE: Pharmacological management of uncooperative children is becoming increasingly common in the dental setting. The purpose of this study was to determine the efficacy and safety of 3 different doses of midazolam for sedation in 2- to 4- year-old children with multiple dental needs and negative behavior.
METHODS: Ten children participated in this crossover, controlled, double-blinded clinical trial, which evaluated their behavior, appointment length and patient response after administration of 3 different doses of midazolam or placebo. Oxygen saturation, heart rate, respiratory rate, and blood pressure were monitored in all sessions.
RESULTS: Sedated children exhibited a more positive behavior compared to the placebo group, both at the beginning of the appointment (sitting in the chair) and during administration of local anesthesia (P=.008 and P<.03, respectively). The use of midazolam allowed for longer appointments, and doses of at least 0.3 mg/kg produced a higher rate of positive behavior overall. No changes in oxygen saturation, heart rate, respiratory rate, and blood pressure were observed.
CONCLUSION: Midazolam was effective and safe for pediatric sedation in the dosages studied.
METHODS: Ten children participated in this crossover, controlled, double-blinded clinical trial, which evaluated their behavior, appointment length and patient response after administration of 3 different doses of midazolam or placebo. Oxygen saturation, heart rate, respiratory rate, and blood pressure were monitored in all sessions.
RESULTS: Sedated children exhibited a more positive behavior compared to the placebo group, both at the beginning of the appointment (sitting in the chair) and during administration of local anesthesia (P=.008 and P<.03, respectively). The use of midazolam allowed for longer appointments, and doses of at least 0.3 mg/kg produced a higher rate of positive behavior overall. No changes in oxygen saturation, heart rate, respiratory rate, and blood pressure were observed.
CONCLUSION: Midazolam was effective and safe for pediatric sedation in the dosages studied.