Atherosclerosis · 2015
Associations of non-invasive measures of arterial structure and function, and traditional indicators of cardiovascular risk in adults with cerebral palsy.
СтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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McPhee Patrick G, Gorter Jan Willem, Cotie Lisa M, Timmons Brian W, Bentley Todd, MacDonald Maureen J
Аннотация
BACKGROUND: Persons with cerebral palsy (CP) have mobility limitations and may be at increased risk for cardiovascular disease (CVD).
AIMS: To determine the feasibility of assessing novel CVD risk indicators and to identify predictors of CVD risk in a clinic-based group of adults with CP.
METHODS: In an observational study, we examined 42 adults with CP (mean age 33.5 ± 12.3 yr). Traditional (resting blood pressure, smoking status and lipids) and novel CVD risk indicators (endothelial function, arterial stiffness, and carotid wall thickness) were assessed.
RESULTS: Measures of endothelial function and central arterial stiffness were conducted in 100% and 83% of participants, respectively. Age was the strongest independent predictor of vascular health (cIMT, Age, R square = 0.576, p = 0.001).
CONCLUSION: Non-invasive measures of arterial structure and function are feasible to assess and may assist in the prediction of CVD risk in adults with CP.
AIMS: To determine the feasibility of assessing novel CVD risk indicators and to identify predictors of CVD risk in a clinic-based group of adults with CP.
METHODS: In an observational study, we examined 42 adults with CP (mean age 33.5 ± 12.3 yr). Traditional (resting blood pressure, smoking status and lipids) and novel CVD risk indicators (endothelial function, arterial stiffness, and carotid wall thickness) were assessed.
RESULTS: Measures of endothelial function and central arterial stiffness were conducted in 100% and 83% of participants, respectively. Age was the strongest independent predictor of vascular health (cIMT, Age, R square = 0.576, p = 0.001).
CONCLUSION: Non-invasive measures of arterial structure and function are feasible to assess and may assist in the prediction of CVD risk in adults with CP.
Предметные рубрики MeSH
AdultAge FactorsBiomarkersBlood PressureCardiovascular DiseasesCarotid Intima-Media ThicknessCerebral PalsyCross-Sectional StudiesDiagnostic Techniques, CardiovascularEndothelium, VascularFeasibility StudiesFemaleHealth StatusHumansLipidsMaleMiddle AgedMobility LimitationOntarioPredictive Value of TestsPrognosisRisk FactorsSmokingVascular StiffnessYoung Adult