The effect of different microtitre plates on the enzyme-linked immunosorbent assay (ELISA) for anticardiolipin antibodies (ACAs).

Studies have shown an association between the presence of ACAs, measured by an ELISA, and thrombosis, foetal loss and thrombocytopenia. Most patients with the syndrome have systemic lupus erythematosus (SLE) or a related autoimmune disease. In studies of the rates of thrombotic episodes in patients with the lupus anticoagulant (LAC) and, or ACAs associated with SLE and non- SLE diseases there is considerable variation. For instance, investigations of women with a poor obstetric history: 13.1% had ACAs, 42.4%, 81.5%, others have found a lower frequency of habitual aborters with the LAC and, or ACAs arguing that ACAs play only a minor role in spontaneous abortion.