The Journal of clinical endocrinology and metabolism · 2017
Insulinlike Growth Factor Binding Protein-1 and Ghrelin Predict Health Outcomes Among Older Adults: Cardiovascular Health Study Cohort.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Kaplan Robert C, Strizich Garrett, Aneke-Nash Chino, Dominguez-Islas Clara, Bužková Petra, Strickler Howard, Rohan Thomas, Pollak Michael, Kuller Lewis, Kizer Jorge R, Cappola Anne, Li Christopher I, Psaty Bruce M, Newman Anne
Аннотация
CONTEXT: Multiple diseases may explain the association of the growth hormone/insulinlike growth factor-I (GH/IGF-I) axis with longevity.
OBJECTIVE: To relate circulating GH/IGF-I system protein levels with major health events.
DESIGN AND SETTING: This is a cohort study set in 4 US communities.
PARTICIPANTS: Adults (N = 2268) 65 years and older free of diabetes and cardiovascular disease.
MEASUREMENTS: We assessed insulinlike growth factor binding protein-1 (IGFBP-1) and ghrelin in fasting and 2-hour oral glucose tolerance test (OGTT) blood samples, as well as fasting IGF-I and IGFBP-3. Hazard ratios for mortality and a composite outcome for first incident myocardial infarction, stroke, heart failure, hip fracture, or death were adjusted for sociodemographic, behavioral, and physiological covariates.
RESULTS: During 13,930 person-years of follow-up, 48.1% of individuals sustained one or more components of the composite outcome and 31.8% died. Versus the lowest quartiles, the highest quartiles of fasting and 2-hour ghrelin were associated with 27% higher (95% confidence interval [CI]: 6%, 53%) and 39% higher (95% CI: 14%, 71%) risks of the composite outcome, respectively. The highest quartile of 2-hour IGFBP-1 was associated with 35% higher (95% CI: 1%, 52%) risk of the composite end point. Similarly, higher mortality was significantly associated with higher fasting and 2-hour ghrelin levels and with 2-hour IGFBP-1 level. When examined together, 2-hour post-OGTT levels of IGFBP-1 and ghrelin tended to predict outcomes better than fasting levels.
CONCLUSIONS: Circulating IGFBP-1 and ghrelin measured during an OGTT predicted major health events and death in older adults, which may explain the influence of the GH/IGF-I axis on lifespan and health.
OBJECTIVE: To relate circulating GH/IGF-I system protein levels with major health events.
DESIGN AND SETTING: This is a cohort study set in 4 US communities.
PARTICIPANTS: Adults (N = 2268) 65 years and older free of diabetes and cardiovascular disease.
MEASUREMENTS: We assessed insulinlike growth factor binding protein-1 (IGFBP-1) and ghrelin in fasting and 2-hour oral glucose tolerance test (OGTT) blood samples, as well as fasting IGF-I and IGFBP-3. Hazard ratios for mortality and a composite outcome for first incident myocardial infarction, stroke, heart failure, hip fracture, or death were adjusted for sociodemographic, behavioral, and physiological covariates.
RESULTS: During 13,930 person-years of follow-up, 48.1% of individuals sustained one or more components of the composite outcome and 31.8% died. Versus the lowest quartiles, the highest quartiles of fasting and 2-hour ghrelin were associated with 27% higher (95% confidence interval [CI]: 6%, 53%) and 39% higher (95% CI: 14%, 71%) risks of the composite outcome, respectively. The highest quartile of 2-hour IGFBP-1 was associated with 35% higher (95% CI: 1%, 52%) risk of the composite end point. Similarly, higher mortality was significantly associated with higher fasting and 2-hour ghrelin levels and with 2-hour IGFBP-1 level. When examined together, 2-hour post-OGTT levels of IGFBP-1 and ghrelin tended to predict outcomes better than fasting levels.
CONCLUSIONS: Circulating IGFBP-1 and ghrelin measured during an OGTT predicted major health events and death in older adults, which may explain the influence of the GH/IGF-I axis on lifespan and health.
Предметные рубрики MeSH
AdultAgedBiomarkersCardiovascular DiseasesCohort StudiesFastingFemaleFollow-Up StudiesGhrelinGlucose Tolerance TestHumansInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ILongitudinal StudiesMaleMiddle AgedPrognosisProspective Studies