Annals of the Academy of Medicine, Singapore · 2003
A case of penicillamine-induced dermopathy.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Tang M B, Chin T M, Yap C K, Ng S K
Аннотация
INTRODUCTION: We describe an interesting patient with penicillamine-induced dermopathy.
CLINICAL PICTURE: A 49-year-old woman presented with a 1-year history of recurrent haemorrhagic blisters, milia and purpura over both her elbows, while on long-term penicillamine therapy (1.5 g daily) for Wilson's disease. Histologically, dermal elastin fibres were markedly reduced in the affected areas, consistent with penicillamine-induced elastolysis.
TREATMENT AND OUTCOME: The patient's lesions improved significantly after reduction of her penicillamine dose to 500 mg daily.
CONCLUSIONS: The cutaneous side effects of long-term penicillamine therapy are important to recognise as they may be associated with significant morbidity and may be markers of more ominous underlying systemic elastic fibre damage.
CLINICAL PICTURE: A 49-year-old woman presented with a 1-year history of recurrent haemorrhagic blisters, milia and purpura over both her elbows, while on long-term penicillamine therapy (1.5 g daily) for Wilson's disease. Histologically, dermal elastin fibres were markedly reduced in the affected areas, consistent with penicillamine-induced elastolysis.
TREATMENT AND OUTCOME: The patient's lesions improved significantly after reduction of her penicillamine dose to 500 mg daily.
CONCLUSIONS: The cutaneous side effects of long-term penicillamine therapy are important to recognise as they may be associated with significant morbidity and may be markers of more ominous underlying systemic elastic fibre damage.