European journal of organic chemistry · 2019
Synthesis of Porphyrin and Bacteriochlorin Glycoconjugates through CuAAC Reaction Tuning.
СтатьяНазвание и аннотация: Перевод в очереди
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Bennion Matthew C, Burch Morgan A, Dennis David G, Lech Melissa E, Neuhaus Kira, Fendler Nikole L, Parris Matthew R, Cuadra Jessica E, Dixon Charlie F, Mukosera George T, Blauch David N, Hartmann Laura, Snyder Nicole L, Ruppel Joshua V
Аннотация
Rapid and reproducible access to a series of unique porphyrin and bacteriochlorin glycoconjugates, including meso-glycosylated porphyrins and bacteriochlorins, and beta-glycosylated porphyrins, via copper catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) is reported for the first time. The work presented highlights the system-dependent reaction conditions required for glycosylation to porphyrins and bacteriochlorins based on the unique electronic properties of each ring system. Attenuated reaction conditions were used to synthesize fifteen new glycosylated porphyrin and bacteriochlorin analogs in 74 - 99% yield, and were extended to solid support to produce the first oligo(amidoamine)-based porphyrin glycoconjugate. These compounds hold significant potential as next generation water soluble catalysts and photodynamic therapy/photodynamic inactivation (PDT/PDI) agents.