Journal of chemotherapy (Florence, Italy) · 2022
Carbapenem-resistant Gram-negative pathogens associated with septic shock: a review of 120 cases.
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Önal Uğur, Akyol Deniz, Mert Merve, Başkol Dilşah, Memetali Seichan Chousein, Şanlıdağ Gamze, Kenanoğlu Buse, Uyan-Önal Ayşe, Quliyeva Günel, Avşar Cansu Bulut, Akdağ Damla, Demir Melike, Erdem Hüseyin Aytaç, Kahraman Ümit, Bozbıyık Osman, Özgiray Erkin, Bozkurt Devrim, Akarca Funda Karbek, Demirağ Kubilay, Çankayalı İlkin, Uyar Mehmet, Çilli Feriha, Arda Bilgin, Yamazhan Tansu, Pullukçu Hüsnü, Taşbakan Meltem Işıkgöz, Sipahi Hilal, Ulusoy Sercan, Sipahi Oguz Resat
Аннотация
This study aimed to evaluate the influencing variables for outcomes in patients with septic shock having culture-proven carbapenem-resistant Gram-negative pathogens. It included 120 patients (mean age 64.29 ± 1.35 years and 58.3% female). The mean Sequential Organ Failure Assessment score during septic shock diagnosis was found to be 11.22 ± 0.43 and 9 ± 0.79 among the patients with mortality and among the survivors, respectively (P = 0.017). The logistic regression analysis showed that empirical treatment as mono Gram-negative bacteria-oriented antibiotic therapy (P = 0.016, odds ratio (OR) = 17.730, 95% confidence interval (CI): 1.728-182.691), Charlson Comorbidity Index >2 (P = 0.032, OR = 7.312, 95% CI: 5.7-18.3), and systemic inflammatory response syndrome score 3 or 4 during septic shock diagnosis (P = 0.014, OR = 5.675, 95% CI: 1.424-22.619) were found as independent risk factors for day 30 mortality. Despite early diagnosis and effective management of patients with septic shock, the mortality rates are quite high in CRGNP-infected patients.