The New England journal of medicine · 2021
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.
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Schultz Nina H, Sørvoll Ingvild H, Michelsen Annika E, Munthe Ludvig A, Lund-Johansen Fridtjof, Ahlen Maria T, Wiedmann Markus, Aamodt Anne-Hege, Skattør Thor H, Tjønnfjord Geir E, Holme Pål A
Аннотация
We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were health care workers who were 32 to 54 years of age. All the patients had high levels of antibodies to platelet factor 4-polyanion complexes; however, they had had no previous exposure to heparin. Because the five cases occurred in a population of more than 130,000 vaccinated persons, we propose that they represent a rare vaccine-related variant of spontaneous heparin-induced thrombocytopenia that we refer to as vaccine-induced immune thrombotic thrombocytopenia.