Fertility and sterility · 2009
Levonorgestrel effects on serum androgens, sex hormone-binding globulin levels, hair shaft diameter, and sexual function.
СтатьяРандомизированное исследованиеПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Kovalevsky George, Ballagh Susan A, Stanczyk Frank Z, Lee Jennifer, Cooper Joann, Archer David F
Аннотация
OBJECTIVE: To determine the effects of levonorgestrel (LNG) on serum androgens, sex hormone-binding globulin (SHBG), hair shaft diameter, and sexual function in women.
DESIGN: Substudy of a prospective randomized double-blind study in women using an LNG SC implant (LNG-SI), who were treated with doxycycline or placebo.
SETTING: Medical school department of obstetrics and gynecology.
PATIENT(S): Forty women were enrolled; 36 completed the study.
INTERVENTION(S): Participants were randomized to doxycycline 20 mg or an identical placebo orally twice a day after LNG-SI insertion.
MAIN OUTCOME MEASURE(S): Serum levels of total T (TT), free T (FT), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), dihydrotestosterone (DHT), androstanediol glucuronide (AG), SHBG, and LNG; hair shaft diameter; and sexual function using the Brief Index of Sexual Function for Women and the Arizona Sexual Experiences Scale were assessed.
RESULT(S): Serum TT, A, DHT, DHEAS, and SHBG declined after LNG-SI insertion. No changes were found in FT, AG, hair shaft diameter, or sexual function. Serum LNG correlated with SHBG levels. There were no differences between the placebo and doxycycline groups.
CONCLUSION(S): LNG reduced serum TT, A, DHT, DHEAS, and SHBG but had no effect on sexual function or markers of androgen bioactivity.
DESIGN: Substudy of a prospective randomized double-blind study in women using an LNG SC implant (LNG-SI), who were treated with doxycycline or placebo.
SETTING: Medical school department of obstetrics and gynecology.
PATIENT(S): Forty women were enrolled; 36 completed the study.
INTERVENTION(S): Participants were randomized to doxycycline 20 mg or an identical placebo orally twice a day after LNG-SI insertion.
MAIN OUTCOME MEASURE(S): Serum levels of total T (TT), free T (FT), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), dihydrotestosterone (DHT), androstanediol glucuronide (AG), SHBG, and LNG; hair shaft diameter; and sexual function using the Brief Index of Sexual Function for Women and the Arizona Sexual Experiences Scale were assessed.
RESULT(S): Serum TT, A, DHT, DHEAS, and SHBG declined after LNG-SI insertion. No changes were found in FT, AG, hair shaft diameter, or sexual function. Serum LNG correlated with SHBG levels. There were no differences between the placebo and doxycycline groups.
CONCLUSION(S): LNG reduced serum TT, A, DHT, DHEAS, and SHBG but had no effect on sexual function or markers of androgen bioactivity.