Journal of breast cancer · 2025
Prognostic Evaluation of the Charlson Comorbidity Index for Breast Cancer Patients by Propensity Score Matching Analysis.
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Shinden Yoshiaki, Eguchi Yuka, Toda Hiroko, Nagata Ayako, Oyabu Akinori, Nakao Rio, Hayashi Naoki, Nomoto Yuki, Minami Koji, Hirashima Tadahiro, Kawasaki Yota, Sasaki Ken, Yoshinaka Heiji, Owaki Tetsuhiro, Tanimoto Akihide, Ohtsuka Takao, Nakajo Akihiro
Аннотация
PURPOSE: The Charlson Comorbidity Index (CCI) is associated with the prognosis of patients with breast cancer. However, comorbidities are often confounded by both age and treatment course; therefore, it is essential to eliminate the influence of these factors. We analyzed the relationship between CCI scores and breast cancer prognosis using propensity score matching (PSM).
METHODS: We retrospectively analyzed 1,403 patients with primary breast cancer who underwent curative surgery. After PSM, 764 patients were selected for analysis of clinicopathological and prognostic factors.
RESULTS: After PSM, prognosis was compared between groups according to several CCI cutoff values. No significant differences in disease-free survival or breast cancer-specific overall survival (OS) were observed according to the CCI score. Similarly, no significant differences in OS were observed between the high- and low-CCI groups at CCI cutoff values of 1 and 2. However, at a CCI cutoff value of 3, OS was significantly worse in patients with higher CCI scores.
CONCLUSION: Among patients with breast cancer, those with CCI scores ≥ 3 often experience mortality due to diseases other than breast cancer.
METHODS: We retrospectively analyzed 1,403 patients with primary breast cancer who underwent curative surgery. After PSM, 764 patients were selected for analysis of clinicopathological and prognostic factors.
RESULTS: After PSM, prognosis was compared between groups according to several CCI cutoff values. No significant differences in disease-free survival or breast cancer-specific overall survival (OS) were observed according to the CCI score. Similarly, no significant differences in OS were observed between the high- and low-CCI groups at CCI cutoff values of 1 and 2. However, at a CCI cutoff value of 3, OS was significantly worse in patients with higher CCI scores.
CONCLUSION: Among patients with breast cancer, those with CCI scores ≥ 3 often experience mortality due to diseases other than breast cancer.