Annales francaises d'anesthesie et de reanimation · 2003
[Risk factors for amoxicillin-clavulanate-resistant Escherichia coli in ICU patients].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Mohammedi I, Denis A, Duperret S, Chapuis F, Ploin D, Petit P
Аннотация
OBJECTIVE: To determine risk factors of infections with amoxicillin-clavulanate-resistant Escherichia coli in ICU patients.
STUDY DESIGN: Prospective, consecutive sample survey study.
PATIENTS: A consecutive series of 133 patients from whom culture results were positive for E. coli during their ICU stay.
METHODS: Risk factors analysed included demographics, comorbid conditions, and antimicrobial drug exposure. Univariate and multivariate analysis were performed.
RESULTS: Multivariate logistic regression analysis identified only one significant independent factor associated with the emergence of amoxicillin-clavulanate-resistant E. coli: prior use of amoxicillin (odds ratio: 5.45).
CONCLUSION: Clinicians should avoid administering amoxicillin-clavulanate as empiric therapy for possible E. coli infection in patients that have recently been treated with amoxicillin.
STUDY DESIGN: Prospective, consecutive sample survey study.
PATIENTS: A consecutive series of 133 patients from whom culture results were positive for E. coli during their ICU stay.
METHODS: Risk factors analysed included demographics, comorbid conditions, and antimicrobial drug exposure. Univariate and multivariate analysis were performed.
RESULTS: Multivariate logistic regression analysis identified only one significant independent factor associated with the emergence of amoxicillin-clavulanate-resistant E. coli: prior use of amoxicillin (odds ratio: 5.45).
CONCLUSION: Clinicians should avoid administering amoxicillin-clavulanate as empiric therapy for possible E. coli infection in patients that have recently been treated with amoxicillin.