Multiple sclerosis journal - experimental, translational and clinical · 2021
Diagnostic value of aquaporin-4-IgG live cell based assay in neuromyelitis optica spectrum disorders.
СтатьяНазвание и аннотация: Перевод в очереди
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Redenbaugh Vyanka, Montalvo Mayra, Sechi Elia, Buciuc Marina, Fryer James P, McKeon Andrew, Lennon Vanda A, Mills John R, Weinshenker Brian G, Wingerchuk Dean M, Chen John J, Tariq Bhatti M, Lopez Chiriboga A Sebastian, Pittock Sean J, Flanagan Eoin P
Аннотация
OBJECTIVE: Determine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay) for Neuromyelitis Optica Spectrum Disorders (NMOSD).
METHODS: We included Mayo Clinic patients (1/1/2018-12/31/2019) tested for serum AQP4-IgG by live cell-based flow-cytometric assay. Medical records were reviewed to assess if patients fulfilled 2015 NMOSD criteria.
RESULTS: Of 1371 patients tested, 41 were positive (3%) and all fulfilled NMOSD criteria with AQP4-IgG (specificity = 100%). Only 10/1330 testing negative met NMOSD criteria without AQP4-IgG (sensitivity = 80%) and seven of these 10 were MOG-IgG positive.
CONCLUSIONS: AQP4-IgG by live cell-based assay was highly specific and without false positives in a high throughput setting.
METHODS: We included Mayo Clinic patients (1/1/2018-12/31/2019) tested for serum AQP4-IgG by live cell-based flow-cytometric assay. Medical records were reviewed to assess if patients fulfilled 2015 NMOSD criteria.
RESULTS: Of 1371 patients tested, 41 were positive (3%) and all fulfilled NMOSD criteria with AQP4-IgG (specificity = 100%). Only 10/1330 testing negative met NMOSD criteria without AQP4-IgG (sensitivity = 80%) and seven of these 10 were MOG-IgG positive.
CONCLUSIONS: AQP4-IgG by live cell-based assay was highly specific and without false positives in a high throughput setting.