Fertility and sterility · 1995
Does intrauterine insemination offer an advantage to cervical cap insemination in a donor insemination program?
Клиническое исследованиеСравнительное исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Williams D B, Moley K H, Cholewa C, Odem R R, Willand J, Gast M J
Аннотация
OBJECTIVE: To compare pregnancy outcome after IUI versus cervical cap insemination in a donor insemination program.
DESIGN: A randomized prospective clinical trial in which patients were alternately inseminated with cryopreserved human semen using either IUI or cervical cap insemination methods.
SETTING: The donor insemination program at Washington University School of Medicine.
PATIENTS: Forty-two women with either isolated male factor or male factor plus corrected ovulatory dysfunction using clomiphene citrate underwent 141 cycles of donor insemination.
MAIN OUTCOME MEASURES: Clinical pregnancy rates (PRs) defined as a viable intrauterine gestation > 12 weeks or delivered were compared between groups using the chi 2 test.
RESULTS: Clinical PRs were significantly higher in the IUI group (16.4%) compared with the cervical cap insemination group (5.9%). The spontaneous abortion rates were similar between the IUI (1.4%) and cervical cap insemination groups (4.4%).
CONCLUSIONS: These findings suggest an advantage to IUI over cervical cap insemination in a donor insemination program.
DESIGN: A randomized prospective clinical trial in which patients were alternately inseminated with cryopreserved human semen using either IUI or cervical cap insemination methods.
SETTING: The donor insemination program at Washington University School of Medicine.
PATIENTS: Forty-two women with either isolated male factor or male factor plus corrected ovulatory dysfunction using clomiphene citrate underwent 141 cycles of donor insemination.
MAIN OUTCOME MEASURES: Clinical pregnancy rates (PRs) defined as a viable intrauterine gestation > 12 weeks or delivered were compared between groups using the chi 2 test.
RESULTS: Clinical PRs were significantly higher in the IUI group (16.4%) compared with the cervical cap insemination group (5.9%). The spontaneous abortion rates were similar between the IUI (1.4%) and cervical cap insemination groups (4.4%).
CONCLUSIONS: These findings suggest an advantage to IUI over cervical cap insemination in a donor insemination program.