Pharmacological reports : PR · 2012
Wheel running decreases the positive reinforcing effects of heroin.
СтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Smith Mark A, Pitts Elizabeth G
Аннотация
BACKGROUND: The purpose of this study was to examine the effects of voluntary wheel running on the positive reinforcing effects of heroin in rats with an established history of drug self-administration.
METHODS: Rats were assigned to sedentary (no wheel) and exercise (wheel) conditions and trained to self-administer cocaine under positive reinforcement contingencies. Rats acquiring cocaine self-administration were then tested with various doses of heroin during daily test sessions.
RESULTS: Sedentary rats self-administered more heroin than exercising rats, and this effect was greatest at low and moderate doses of heroin.
CONCLUSION: These data suggest that voluntary wheel running decreases the positive reinforcing effects of heroin.
METHODS: Rats were assigned to sedentary (no wheel) and exercise (wheel) conditions and trained to self-administer cocaine under positive reinforcement contingencies. Rats acquiring cocaine self-administration were then tested with various doses of heroin during daily test sessions.
RESULTS: Sedentary rats self-administered more heroin than exercising rats, and this effect was greatest at low and moderate doses of heroin.
CONCLUSION: These data suggest that voluntary wheel running decreases the positive reinforcing effects of heroin.