Squamous papilloma of the esophagus - a clinicopathologic study of 10 cases and review of the literature.

Esophageal squamous papilloma (ESP) is considered to be a rare finding during endoscopy or autopsy. Over a 10 year period, 10 cases were identified among 14,232 patients who were endoscoped in the King Khalid University Hospital (KKUH), Riyadh. The calculated incidence was 0.07%. There were eight males and two females whose ages ranged from 24 to 65 years. The presenting symptoms were mostly dyspepsia and heartburn. All the ESPs were single growth, most of which were located in the lower segment of the esophagus. Immunoperoxidase staining was negative for human papilloma virus in all the tissue samples. It is calculated that ESPs may not be very rare in the Saudi population. Awareness of its occurrence may lead to increasing diagnosis among endoscopy patients.