Asia-Pacific journal of clinical oncology · 2012
Clinical and laboratory features of adult biphenotypic acute leukemia.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Tong Haixia, Liu Zhuogang, Lu Chunwei, Wang Qiushi
Аннотация
AIM: To analyze the clinical and biological characteristics of adult BAL.
METHODS: We identified 22 cases (4.4%) of BAL from 496 newly diagnosed acute leukemia patients and compared them with patients with acute myloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
RESULTS: CD34 positivity was higher in BAL (87%) than in ALL (60%, P = 0.04) and AML patients (63%, P = 0.05). The median age in the BAL group was greater than in ALL (43 vs 31 years, P = 0.04). Enlargement of liver, spleen and lymphonodes was more common in BAL (81.8%) than AML (46%, P = 0.003). Cytogenetic analysis revealed abnormal karyotypes in 56% of BAL patients. The overall completed remission rate in the BAL group (65%) was lower than in ALL (86%, P = 0.04).
CONCLUSION: BAL patients showed a much higher incidence of older age, CD34 antigen expression, presence of Philadelphia chromosome, liver, spleen and lymphonodes infiltration and resistance to therapy.
METHODS: We identified 22 cases (4.4%) of BAL from 496 newly diagnosed acute leukemia patients and compared them with patients with acute myloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
RESULTS: CD34 positivity was higher in BAL (87%) than in ALL (60%, P = 0.04) and AML patients (63%, P = 0.05). The median age in the BAL group was greater than in ALL (43 vs 31 years, P = 0.04). Enlargement of liver, spleen and lymphonodes was more common in BAL (81.8%) than AML (46%, P = 0.003). Cytogenetic analysis revealed abnormal karyotypes in 56% of BAL patients. The overall completed remission rate in the BAL group (65%) was lower than in ALL (86%, P = 0.04).
CONCLUSION: BAL patients showed a much higher incidence of older age, CD34 antigen expression, presence of Philadelphia chromosome, liver, spleen and lymphonodes infiltration and resistance to therapy.
Предметные рубрики MeSH
AdolescentAdultAge FactorsAgedAntineoplastic Combined Chemotherapy ProtocolsFemaleFollow-Up StudiesHumansImmunophenotypingInduction ChemotherapyKaryotypingLeukemia, Biphenotypic, AcuteLeukemia, Myeloid, AcuteMaleMiddle AgedPhiladelphia ChromosomePrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisRemission InductionRetrospective StudiesYoung Adult