Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians · 2003
Oral treatment of avian lead intoxication with meso-2,3-dimercaptosuccinic acid.
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Hoogesteijn Almira L, Raphael Bonnie L, Calle Paul, Cook Robert, Kollias George
Аннотация
The efficacy of meso-dimercaptosuccinic acid (DMSA) (succimer) in treating avian lead intoxication was studied in a retrospective, nonrandomized, longitudinal study. Nineteen birds with moderate to high blood lead concentration and neurologic signs compatible with lead toxicity were treated with DMSA (30 mg/kg p.o., b.i.d.; n = 15) for a minimum of 7 days. In cases with severe neurologic signs, DMSA was supplemented with a single dose of edetate calcium disodium (<50.0 mg/kg of body weight i.m.; n = 4). Blood lead concentrations were measured two or more times (before and after treatment). Median blood lead concentration decreased (87%), neurologic signs were resolved, and there were no apparent adverse secondary effects.