Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018
Riligustilide Attenuated Renal Injury by the Blockade of Renin.
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Kong Juan, Han Li, Su Han, Hu Yihan, Huang Xueshi, Lou Yan
Аннотация
BACKGROUND/AIMS: Nephropathy related with renin can be alleviated with ACE-inhibitors or AT1R blockers, whereas they might be ineffective after long-term administration because of a feedback production of enhanced renin. Therefore, it is urgent to develop a new category of anti-nephropathy medicine directly targeting renin. Riligustilide (C20), originally isolated from the Chinese herb Ligusticumporteri, a rhizome, was confirmed effective against many diseases.
METHODS: The therapeutic effect of C20 on renal injury and its underlying mechanism were investigated in three different nephrotic models, which were spontaneously hypertension rats (SHR) model, diabetic nephropathy in BTBR ob/ob mice model and 5/6-nephrectomized (5/6NX) rats model.
RESULTS: The intensity of kidney fibrosis was extensively decreased in the C20-treated rats compared to the vehicle animals. C20 significantly alleviated renal injury much more in 5/6 NX rats than in vehicle group. The rats in 5/6 NX without administrated C20 developed albuminuria earlier with more severe symptoms. Additionally, our findings showed that C20 down-regulated the renin expression and relocation of CREB-CBP complex in vivo and in vitro.
CONCLUSION: C20 plays importantly reno-protective roles most likely through the relocation of CREB-CBP complex.
METHODS: The therapeutic effect of C20 on renal injury and its underlying mechanism were investigated in three different nephrotic models, which were spontaneously hypertension rats (SHR) model, diabetic nephropathy in BTBR ob/ob mice model and 5/6-nephrectomized (5/6NX) rats model.
RESULTS: The intensity of kidney fibrosis was extensively decreased in the C20-treated rats compared to the vehicle animals. C20 significantly alleviated renal injury much more in 5/6 NX rats than in vehicle group. The rats in 5/6 NX without administrated C20 developed albuminuria earlier with more severe symptoms. Additionally, our findings showed that C20 down-regulated the renin expression and relocation of CREB-CBP complex in vivo and in vitro.
CONCLUSION: C20 plays importantly reno-protective roles most likely through the relocation of CREB-CBP complex.
Предметные рубрики MeSH
Angiotensin-Converting Enzyme InhibitorsAnimalsBenzofuransCREB-Binding ProteinCell LineDiabetic NephropathiesDisease Models, AnimalDown-RegulationKidneyMaleMedicine, Chinese TraditionalMembrane ProteinsMiceMice, KnockoutMice, ObeseMolecular Docking SimulationNephrectomyPhosphoproteinsRatsRats, Inbred SHRReninRenin Inhibitors