International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Vita Serena, Di Bari Virginia, Corpolongo Angela, Goletti Delia, Espinosa Joaquin, Petracca Sebastiano, Palmieri Fabrizio, Nicastri Emanuele, INMI COVID-19 study groups
Аннотация
We report two cases of Corona Virus Disease-19 (COVID-19) in patients with Down Syndrome (DS) and describe the identification, diagnosis, clinical course and management of the infection. Down Syndrome, which is caused by trisomy 21, is characterized by immune dysregulation, anatomical differences in the upper respiratory tract and higher rate of comorbidities. All these risk factors can contribute to more severe clinical presentations of COVID-19 in this population. It is essential to raise awareness of the clinical relevance of SARS-COV-2 infection in DS patients, as well as in other most vulnerable patients, in order to improve their management and treatment and to encourage vaccinating these individuals early, once a vaccination is available.