Pharmacogenomics · 2012
UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Tian Jia-Ni, Ho Ing-Kang, Tsou Hsiao-Hui, Fang Chiu-Ping, Hsiao Chin-Fu, Chen Chia-Hui, Tan Happy Kuy-Lok, Lin Linen, Wu Chi-Shin, Su Lien-Wen, Huang Chieh-Liang, Yang Yi-Hong, Liu Ming-Lun, Chen Yu-Ting, Liu Shu Chih, Hsu Ya-Ting, Kuo Hsiang-Wei, Liu Chen Ting, Yang Yi-Ting, Chen Andrew Ch, Shih Yu-Huei, Liu Yu-Li
Аннотация
AIM: To test whether the genetic polymorphisms within the gene encoding the UGT2B7 gene may have an impact on methadone treatment.
MATERIALS & METHODS: Twelve SNPs in UGT2B7 were selected. 366 methadone maintenance treatment patients in Taiwan were recruited and genotyped.
RESULTS: In a genotype recessive model, rs6600879, rs6600880, rs4554144, rs11940316, rs7438135, rs7662029, rs7668258, rs7439366, rs4292394 and rs6600893 showed significant associations with severity of withdrawal symptoms (permutation p < 0.002), pupil size (permutation p < 0.048) and tremor (permutation p < 0.008). Haplotypes of GATCAGCCGC and CTCTGATTCT were significantly associated with pupil size score and tremor score (p < 0.034).
CONCLUSION: These results suggest that SNPs of the UGT2B7 gene may play important roles in opiate withdrawal symptoms.
MATERIALS & METHODS: Twelve SNPs in UGT2B7 were selected. 366 methadone maintenance treatment patients in Taiwan were recruited and genotyped.
RESULTS: In a genotype recessive model, rs6600879, rs6600880, rs4554144, rs11940316, rs7438135, rs7662029, rs7668258, rs7439366, rs4292394 and rs6600893 showed significant associations with severity of withdrawal symptoms (permutation p < 0.002), pupil size (permutation p < 0.048) and tremor (permutation p < 0.008). Haplotypes of GATCAGCCGC and CTCTGATTCT were significantly associated with pupil size score and tremor score (p < 0.034).
CONCLUSION: These results suggest that SNPs of the UGT2B7 gene may play important roles in opiate withdrawal symptoms.