Molecules (Basel, Switzerland) · 2011
Polycationic glycosides.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Engel Robert, Ghani Ishrat, Montenegro Diego, Thomas Marie, Klaritch-Vrana Barbara, Castaño Alejandra, Friedman Laura, Leb Jay, Rothman Leah, Lee Heidi, Capodiferro Craig, Ambinder Daniel, Cere Eva, Awad Christopher, Sheikh Faiza, Rizzo Jaimelee, Nesbitt Lisa-Marie, Testani Erika, Melkonian Karin
Аннотация
Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.