JACC. Basic to translational science · 2021
Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.
СтатьяНазвание и аннотация: Перевод в очереди
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Gibb Andrew A, Murray Emma K, Eaton Deborah M, Huynh Anh T, Tomar Dhanendra, Garbincius Joanne F, Kolmetzky Devin W, Berretta Remus M, Wallner Markus, Houser Steven R, Elrod John W
Аннотация
In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1-month post-banding, revealed loss of electron transport chain components, and this was supported by changes in metabolism and mitochondrial function, altogether signifying alterations in oxidative metabolism. Established HFpEF, 4 months post-banding, resulted in changes in intermediary metabolism with normalized mitochondrial function. Mitochondrial dysfunction and energetic deficiencies were noted in skeletal muscle at early and late phases of disease, suggesting cardiac-derived signaling contributes to peripheral tissue maladaptation in HFpEF. Collectively, these results provide insights into the cellular biology underlying HFpEF progression.